Conolidine’s analgesic effects stem from its conversation with non-opioid pain pathways. In contrast to opioids, which bind to µ-opioid receptors during the central anxious procedure, conolidine modulates alternate molecular targets. A Science Innovations study found that conolidine interacts with the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://reidafhoq.mybuzzblog.com/18965896/the-basic-principles-of-alternative-natural-pain-relief-to-replace-traditional-painkillers