TAK-243 preferentially certain to UBA1 more than the similar E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 lowered levels of ubiquitylated proteins, increased markers of proteotoxic tension and DNA harm tension. In vivo, TAK-243 reduced leukemic stress and focused leukemic stem cells devoid https://shanefyqiy.dailyblogzz.com/29664555/not-known-factual-statements-about-ponicidin