The recognized effect of those PTMs on ATXN2’s function and SCA2 pathogenesis continues to be minimal. In other polyQ disorders, multiple studies suggested that proteolytic cleavage of polyQ proteins could Participate in a very important job in pathogenesis [36, forty five]. Aligned with this particular concept, the existence of an https://waylongoufo.humor-blog.com/27760583/isa-2011b-for-dummies